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The symposium aims to unite the field of mechanobiology, by bringing together world-leading experts in the generation and sensing of forces from the molecular scale to the organismal scale. An important emphasis will be the combination of physics and computer modelling with molecular genetics and live-imaging in vitro or in vivo. The field is currently expanding rapidly and we aim to provide a comprehensive overview of this progress as well as aiming to capitalise on the opportunities for new collaborations.